A synthetic pentapeptide that reduces wrinkles by mimicking enkephalin's muscle-relaxing effects — a Botox-alternative peptide.
Leuphasyl (Pentapeptide-18) is a synthetic pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) that functions as an enkephalin mimetic in cosmetic applications. It reduces facial wrinkle depth by decreasing neurotransmitter release at the neuromuscular junction — similar in concept to botulinum toxin but applied topically and with much milder effects.
Leuphasyl acts through a different mechanism than SNAP-8 (which targets the SNARE complex directly). Instead, it mimics the action of enkephalins — natural opioid peptides that reduce neuronal excitability and neurotransmitter release. By reducing acetylcholine release at facial muscles, it decreases the muscle contractions that create expression lines and wrinkles.
In cosmetic formulations, Leuphasyl is often combined with Argireline (Acetyl Hexapeptide-3) and SNAP-8 (Acetyl Octapeptide-3) for synergistic anti-wrinkle effects through complementary mechanisms.
Manufacturer studies show Leuphasyl reduces wrinkle depth by up to 11% in 28 days when used alone, and up to 24% when combined with Argireline — demonstrating synergistic effects with other neuropeptide-based anti-wrinkle actives.
The enkephalin-mimetic mechanism is well-characterized in neuropharmacology. Topical delivery limits systemic absorption, providing a favorable safety profile for cosmetic use.
Excellent topical safety profile. No systemic absorption concerns at cosmetic concentrations. Skin irritation is rare. Not intended for injection.
Cosmetic ingredient. Not regulated as a drug. Widely available in skincare formulations.